Skip to main content

Table 1 Comparison: hematological malignancies (HMs) vs solid tumors (STs)

From: Differential cardiac impacts of hematological malignancies and solid tumors: a histopathological and biomarker study

 

HM

(n = 198)a

ST

(n = 164)a

p Value

Demographic parameters

 Age (yrs)

58 (14)

62 (13)

0.007

 Race

  

0.2

 White

161 (81%)

120 (73%)

 

 Black

21 (11%)

20 (12%)

 

 Hispanic

4 (2.0%)

4 (2.4%)

 

 Other Race

12 (6.1%)

20 (12%)

 

 Female

70 (35%)

64 (39%)

0.5

 Body mass index (kg/m2)

30 (9)

28 (8)

0.022

 Tobacco use

115 (62%)

115 (74%)

0.023

Cardiac biomarkers

 Ejection fraction (%)

59 (15)

64 (12)

0.090

 B-type natriuretic peptide (pg/ml)

2,275 (4,279)

867 (1,317)

 < 0.001

 Troponin I (ng/ml)

1.7 (4.8)

4.6 (17.2)

0.13

 Creatine Kinase MB (ng/ml)

7 (17)

12 (29)

0.2

 Hemoglobin (g/dl)

6.71 (1.36)

8.06 (1.97)

 < 0.001

Post-mortem parameters

 Atherosclerosis (more than mild)

72 (43%)

74 (50%)

0.2

 Heart weight (g)

487 (126)

440 (129)

0.001

 Left ventricle thickness (cm)

1.62 (0.36)

1.63 (0.41)

0.9

 Right ventricle thickness (cm)

0.55 (0.21)

0.53 (0.23)

0.4

 Septal wall thickness (cm)

1.51 (0.45)

1.50 (0.39)

0.8

Myocardial morphology

 Collagen fiber alignment

0.71 (0.23)

0.83 (0.12)

0.027

 Interstitial fibrosis (%)

0.25 (0.10)

0.26 (0.12)

0.9

 Cardiomyocyte nuclei (#)

56 (19)

72 (23)

0.002

Cardiomyocyte minor axis length (µm)

25 (3)

25 (3)

0.42

  1. aValues are mean (SD); n (%)