Table 1 Baseline characteristics of patients with cll stratified according to hospital blood malignancy proportion

No. patients

6357

305

909

1134

1617

2392

No. hospitals

4316

274

731

872

1062

1377

Age (y),median (IQR)

76 (69,82)

75 (68,82)

76 (69,82)

77 (70,83)

77 (69,82)

76 (69,82)

.179

Age at admission

 18 ~ 54

151 (2.3)

10 (3.2)

21 (2.3)

27 (2.4)

28 (1.7)

65 (2.7)

.165

 55 ~ 64

697 (11.0)

39 (12.8)

90 (9.9)

116 (10.2)

171 (10.6)

281 (11.8)

 65 ~ 74

1835 (28.9)

96 (31.5)

285 (31.4)

320 (28.2)

481 (29.8)

653 (27.3)

 75 + 

3674 (57.8)

160 (52.5)

513 (56.4)

671 (59.2)

937 (57.9)

1393 (58.2)

Gender

 Male

4590 (72.2)

220 (72.1)

670 (73.7)

824 (72.7)

1132 (70.0)

1744 (72.9)

.229

 Female

1767 (27.8)

85 (27.9)

239 (26.3)

310 (27.3)

485 (30.0)

648 (27.1)

Race

 White

5373 (89.3)

230 (76.7)

768 (87.7)

976 (90.2)

1375 (90.0)

2024 (90.0)

 <.0001

 Black

272 (4.5)

25 (8.3)

50 (5.7)

43 (4.0)

68 (4.5)

86 (3.8)

 Hispanic

181 (3.0)

26 (8.7)

33 (3.8)

37 (3.4)

34 (2.3)

51 (2.3)

 Asian/Pacific Islander

42 (0.7)

3 (1.0)

7 (0.8)

12 (1.1)

6 (0.4)

14 (0.6)

 Native American

14 (0.2)

5 (1.7)

1 (0.1)

0

3 (0.2)

5 (0.2)

 Other

138 (2.3)

11 (3.7)

17 (1.9)

14 (1.3)

26 (1.72)

70 (3.1)

 Missing data

337

5

33

52

105

142

Year

 2010

511 (8.0)

6 (2.0)

24 (2.6)

76 (6.7)

173 (10.7)

232 (9.7)

 <.0001

 2011

551 (8.7)

4 (1.3)

22 (2.4)

45 (4.0)

167 (10.3)

313 (13.1)

 2012

448 (7.1)

6 (2.0)

17 (1.9)

38 (3.4)

144 (8.9)

243 (10.2)

 2013

563 (8.9)

7 (2.3)

21 (2.3)

50 (4.4)

164 (10.1)

321 (13.4)

 2014

524 (8.2)

2 (0.7)

23 (2.5)

38 (3.4)

126 (7.8)

335 (14.0)

 2015

576 (9.1)

3 (1.0)

39 (4.3)

59 (5.2)

196 (12.1)

279 (11.7)

 2016

483 (7.6)

52 (17.1)

118 (13.0)

117 (10.3)

101 (6.3)

95 (4.0)

 2017

497 (7.8)

51 (16.7)

134 (14.7)

139 (12.2)

81 (5.0)

92 (3.9)

 2018

498 (7.8)

51 (16.7)

117 (12.9)

137 (12.1)

90 (5.6)

103 (4.3)

 2019

558 (8.8)

35 (11.5)

136 (15.0)

140 (12.4)

120 (7.4)

127 (5.3)

 2020

570 (9.0)

30 (9.8)

131 (14.4)

156 (13.8)

132 (8.2)

121 (5.1)

 2021

578 (9.1)

58 (19.0)

127 (14.0)

139 (12.3)

123 (7.6)

131 (5.5)

CCI

 0 ~ 4

80 (1.3)

4 (1.3)

7 (0.8)

15 (1.3)

15 (0.9)

39 (1.6)

.002

 5 ~ 6

1060 (16.7)

35 (11.5)

132 (14.5)

168 (14.8)

278 (17.2)

447 (18.7)

 7 ~ 8

2412 (37.9)

112 (36.7)

343 (37.7)

429 (37.8)

609 (37.7)

919 (38.4)

 9 + 

2805 (44.1)

154 (50.5)

427 (47.0)

522 (46.0)

715 (44.2)

987 (41.3)

Insurance type

 Medicare

5175 (81.5)

244 (80.0)

749 (82.5)

934 (82.5)

1317 (81.5)

1931 (80.7)

.635

 Medicaid

111 (1.8)

10 (3.3)

12 (1.3)

15 (1.3)

31 (1.9)

43 (1.8)

 Private including HMO

890 (14.0)

42 (13.8)

125 (13.8)

153 (13.5)

218 (13.5)

352 (14.7)

 Self-pay

38 (0.6)

0

2 (0.2)

7 (0.6)

11 (0.7)

18 (0.8)

 No charge

3 (0.1)

0

0

0

1 (0.1)

2 (0.1)

 Other

136 (2.1)

9 (3.0)

20 (2.2)

23 (2.0)

38 (2.4)

46 (1.9)

 Missing data

4

0

1

2

1

0

Hospital bed size

 Small

614 (10.7)

54 (22.0)

136 (17.5)

116 (11.7)

152 (10.2)

156 (6.9)

 <.0001

 Medium

1407 (24.4)

91 (37.1)

269 (34.5)

305 (30.7)

373 (25.0)

369 (16.4)

 Large

3744 (64.9)

100 (40.8)

374 (48.0)

572 (57.6)

969 (64.9)

1729 (76.7)

 Missing data

592

100

130

141

123

138

Hospital location

 Rural

267 (4.6)

22 (9.0)

33 (4.2)

52 (5.2)

89 (6.0)

71 (3.2)

 <.0001

 Urban non-teaching

1377 (23.9)

63 (25.7)

200 (25.7)

245 (2.7)

406 (27.2)

463 (20.5)

 Urban teaching

4121 (71.5)

160 (65.3)

546 (70.1)

696 (70.1)

999 (66.9)

1720 (76.3)

 Missing data

592

60

130

141

123

138

Ownership

 Government, nonfederal

440 (7.6)

21 (8.6)

62 (8.0)

54 (5.4)

110 (7.4)

193 (8.6)

 <.0001

 Private, non-profit

4636 (80.4)

137 (55.9)

536 (68.8)

831 (83.7)

1227 (82.1)

1905 (84.5)

 Private, invest-own

689 (12.0)

87 (35.5)

181 (23.2)

108 (10.9)

157 (10.5)

156 (6.9)

 Missing data

592

60

130

141

123

138

Comorbidities

 CHF

2854 (44.9)

156 (51.2)

445 (49.0)

542 (47.8)

691 (42.7)

1020 (42.6)

 <.0001

 Coronary artery disease

2887 (45.4)

155 (50.8)

438 (48.2)

536 (47.3)

701 (43.4)

1057 (44.2)

.016

 Atrial fibrillation

2585 (40.7)

120 (39.3)

365 (40.2)

441 (38.9)

638 (39.5)

1021 (42.67)

.146

 Prior MI

852 (13.4)

37 (12.1)

113 (12.4)

167 (14.7)

223 (13.8)

312 (13.0)

.501

 Cardiogenic shock

337 (5.3)

22 (7.2)

51 (5.6)

64 (5.6)

71 (4.4)

129 (5.4)

.252

 Endocarditis

64 (1.0)

2 (0.7)

5 (0.6)

4 (0.4)

22 (1.4)

31 (1.3)

.025

 Pneumonia

207 (3.3)

5 (1.6)

13 (1.4)

20 (1.8)

69 (4.3)

100 (4.2)

 <.0001

 Urinary Tract Infection

451 (7.1)

22 (7.2)

71 (7.8)

77 (6.8)

111 (6.9)

170 (7.1)

.909

 Intracerebral Hemorrhage

10 (0.2)

1 (0.3)

0

3 (0.3)

2 (0.1)

4 (0.2)

.565

 Chronic renal failure

1812 (28.5)

95 (31.2)

271 (29.8)

333 (29.4)

467 (28.9)

646 (27.0)

.291

 COPD

1402 (22.1)

64 (21.0)

211 (23.2)

240 (21.2)

3373 (23.1)

514 (21.5)

.584

 Obstructive sleep apnea

643 (10.1)

31 (10.2)

93 (10.2)

138 (12.2)

160 (9.9)

221 (9.2)

.117

 Pulmonary Embolism

11 (0.2)

0

2 (0.2)

2 (0.2)

2 (0.1)

5 (0.2)

.902

 Coagulopathy

1512 (23.8)

77 (25.3)

195 (21.5)

295 (26.1)

406 (25.1)

539 (22.5)

.044

 Anemia

2426 (38.2)

119 (39.0)

332 (36.5)

429 (37.8)

658 (40.7)

888 (37.12)

.155

 Diabetes

1608 (25.3)

86 (28.2)

236 (26.0)

282 (24.9)

452 (28.0)

552 (23.1)

.007

 Hypertension

3301 (51.9)

161 (52.8)

490 (53.9)

636 (56.1)

820 (50.7)

1194 (49.9)

.007

 Liver Disease

131 (2.1)

7 (2.3)

15 (1.7)

25 (2.2)

34 (2.1)

50 (2.1)

.912

 Obesity

855 (13.5)

48 (15.7)

133 (14.6)

181 (16.0)

215 (13.3)

278 (11.6)

.004

 Alcohol use

83 (1.3)

4 (1.3)

10 (1.1)

11 (1.0)

25 (1.6)

33 (1.4)

.714

 Smoking

2271 (35.7)

116 (38.0)

359 (39.5)

449 (39.6)

530 (32.8)

817 (34.2)

.000

 Syncope

157 (2.5)

6 (2.0)

18 (2.0)

34 (3.0)

39 (2.4)

60 (2.5)

.631

 Dyslipidemia

3472 (54.6)

163 (53.4)

509 (56.0)

627 (55.3)

882 (54.6)

1291 (54.0)

.830